“Mesotherapy” is a non-surgical, minimally invasive method of drug delivery that consists of multiple intradermal or subcutaneous injections of a mixture of compounds “melange” in minute doses. Plant extracts, homeopathic agents, pharmaceuticals, vitamins and other bioactive substances can be used, but alcohol- or oil-based substances should not be used for mesotherapy because of the risk of cutaneous necrosis.
The term “mesotherapy” is derived from the Greek words “mesos” meaning “middle” or “mean” and “therapeia” meaning “to treat medically,” i.e. injecting into the middle layer of skin or “intradermotherapy.”
Deepthi Konda, Devinder M. Thappa, september 2012.
The depth of penetration of the needle should not exceed 4 mm for it to be effective. Despite it being available for over 50 years and the huge publicity and attention received on the Internet, definite evidence for its efficacy is lacking and the claims are not always based on well-conducted clinical trials.
Mesotherapy for the first time was developed in 1952 by Dr. Michel Pistor, a French physician for the management of pain and vascular disorders. Pistor coined the term “mesotherapy.” He defined it as treatment of the mesoderm (the primary germ layer that
develops into connective tissue, muscle and circulatory system). In 1976, he used the following words to describe mesotherapy: “little volume, few times and in the right place.”Pistor founded the Fench Society of Mesotherapy in 1964 and, in 1987, The French National Academy of Medicine officially acknowledged mesotherapy as
a medical specialty. In the meantime, mesotherapy became popular in most parts of Europe and South America and, more recently, in the United States and Asian countries.
INDICATIONS OF MESOTHERAPY
Mesotherapy, like corticosteroids, is claimed to have a wide array of applications specially in the field of cosmetic dermatology. However, only the current and widely practised indications in the field of dermatology along with the drugs used in them are
1. Body–cellulite, lipodissolve, body contouring (not
2. Skin–rejuvenation/glow, lift, pigmentation
3. Hair–telogen effluvium, androgenetic alopecia
Cellulite, local fat deposits and facial rejuvenation show good results with mesotherapy; telogen effluvium, androgenetic alopecia, stretch marks and facial pigmentation show moderate results; whereas body sculpting/contouring and melasma show doubtful results with the same…